The scene depicting 'The Rest on the Flight into Egypt' by Federico Cantú  is indebted to Albrecht Dürer’s work. Both works are characterised by a touching domesticity, showing the Holy Family tired after their long journey.

The flight into Egypt is a biblical event described in the Gospel of Matthew (Matthew 2:13-23), in which Joseph fled to Egypt with Mary and infant son Jesus after a visit by Magi because they learned that King Herod intended to kill the infants of that area. The episode is frequently shown in art, as the final episode of the Nativity of Jesus in art, and was a common component in cycles of the Life of the Virgin as well as the Life of Christ.